Previous studies have shown that EVA1A is expressed in a cell-type- and tissue-type-specific manner, and is significantly downregulated in cancer tissues.18, 19, 20 Furthermore, in vivo and in vitro experiments have demonstrated that EVA1A overexpression inhibits tumour cell proliferation by both autophagy and apoptosis.19, 20 Latest research shows that Eva1a deletion impairs the generation of newborn neurons by activating the PIK3CA–AKT axis and inhibiting autophagy.21 However, its role in cardiac remodelling remains to be elucidated. This evidence concerns the gene EVA1A and neoplasm.