Growing evidence suggests that CGRP prevents excessive immune activation, inhibiting proinflammatory cytokine injury and maintaining a balance between pro- and anti-inflammation without the pancreas.22 Moreover, CGRP reduced the leukocyte infiltration into the pancreatic tissue and increased the pancreatic blood flow, permitting removal of active digestive enzymes and mediators of inflammation, thereby attenuating the pancreatic damage in pancreatitis.10, 23 The present study found that the CALCB splice region variants (CALCB_p.S30P and IR [1]) resulted in a decreased βCGRP. This evidence concerns the gene CALCA and pancreatitis.