CALCB S30P mutation led to genes expression changes, which were associated with Glycolysis/Gluconeogenesis, Ubiquinone and other terpenoid-quinone biosynthesis, Morphine addiction, and Glycosphingolipid biosynthesis-globo series, activity up- or down-regulated, whereas most genes were involved in ‘Organismal Injury', ‘Gastrointestinal Disease', and ‘Hereditary Disorder'. Here, CALCB is linked to gastrointestinal disease.