In subsequent work (Chapuis et al., 2013; Moreau et al., 2014; Shulman et al., 2014), we and others discovered that fly homologs of several genes at loci implicated by GWAS, including BIN1, PICALM, CD2AP, CELF1 and FERMT2, can interact with MAPT toxicity in vivo, providing mechanistic insight into their potential links with Alzheimer's disease risk in humans. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.