PDGFRB and Alzheimer disease: We previously reported on chronic hypoperfusion (reduction in MAG:PLP1) in theparietal white matter in AD.24 Unlike in the precuneus, PDGFRB level in the white matter correlatednegatively with MAG:PLP1 (r = −0.31, P = 0.004) (Figure 6(a)) andpositively with VEGF (r = 0.19, P = 0.019) (Figure 6(b)) indicating anincrease in PDGFRB with declining white matter perfusion.