PLP1 and Alzheimer disease: We previously reported that MAG:PLP1 was reduced in the precuneus from an earlystage of AD, indicating a perfusion deficit with respect to the energy requirements.26 In the present study, PDGFRB level correlated positively with MAG:PLP1(r = +0.34, P = 0.006) and negatively with VEGF level(r = −0.26, P = 0.029), providing evidence that pericyte loss is associated withcerebral hypoperfusion (Figure3(a) and (b)).