Experimental disease models indicate that although mice lacking P-Selectin, E-Selectin or both are significantly protected from neutrophil-dependent injury5, 23, 24, selectin deficiency induced disease exacerbation in models of glomerulonephritis or collagen-induced arthritis, suggesting a protective role for endothelial P-Selectin in inflammation5, 25, 26. Here, SELP is linked to glomerulonephritis.