Finally, it has been reported that the lack of either P-Selectin or PSGL-1 in murine lupus models enhances both skin and renal inflammation29 and that the tissue expression of P- and E-Selectin in the MLR/lpr mice was not upregulated regarding the non-inflammed MRL+/+ mice55. This evidence concerns the gene SELP and systemic lupus erythematosus.