NFE2L2 and chronic myelogenous leukemia, BCR-ABL1 positive: Moreover, p65 was reduced by Wogonin in the nucleus of resistant CML cells, and the analysis showed reduction of both Nrf2 and p65 nuclear protein levels to correlate in a 1:1 manner (Fig. 2A and B, also in Supplementary Fig. 2A and B).