Recently, Kweon et al. 30 reported that epigallocatechin 3-gallate (EGCG), the major polyphenol found in green tea, suppressed HO-1 expression by inactivation of Nrf2 in non-small-cell lung cancer (NSCLC) A549 cells. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.