While orthotopic liver transplantation (OLT) is the major curative approach for BSEP-deficiency2, 10, some BSEP-deficient patients treated with OLT experience a relapse of intrahepatic cholestasis due to the presence of autoimmune antibodies against BSEP11, 12. The gene discussed is ABCB11; the disease is intrahepatic cholestasis.