SCN2A and epilepsy: Notably, mutations in Nav1.1, Nav1.2, Nav1.3, and Nav1.6 mainly cause epilepsies; those in Nav1.4 are related to myopathies; in Nav1.5 result in cardiac channelopathies; and in Nav1.7, Nav1.8, and Nav1.9 are associated with pain-related diseases (Fig. 3 and Tables 1, 2, 3, 4, 5, 6, 7, 8, 9, 10).