Two trials evaluating the safety, tolerability, pharmacokinetics, and antitumor activity of avitinib are ongoing; a phase I/II trial (NCT02274337) in advanced NSCLC patients progressing on prior therapy with an EGFR TKI agent and a phase I trial (NCT02330367) designed to determine the MTD and/or recommended phase 2 dose in previously treated mutant EGFR NSCLC patients with a T790M resistant mutation. This evidence concerns the gene EGFR and non-small cell lung carcinoma.