Following this strategy, a phase I trial was designed to evaluate the safety of two osimertinib-based combination strategies, with necitumumab or ramucirumab (an anti-VEGFR2 monoclonal antibody) in patients with advanced EGFR T790M+ NSCLC after progression on first-line EGFR TKI therapy (NCT02789345). This evidence concerns the gene EGFR and non-small cell lung carcinoma.