Dual EGFR blockage is being evaluated in a phase I trial (NCT02496663) combining osimertinib with the anti-EGFR monoclonal antibody necitumumab to assess safety and determine the optimal dose in patients with EGFR-mutant advanced NSCLC who have progressed on a previous EGFR TKI. Here, EGFR is linked to non-small cell lung carcinoma.