EGFR and non-small cell lung carcinoma: In this review, we outline available post-progression therapies including osimertinib (previously known as AZD9291) as the only drug approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of patients with metastatic EGFR T790M+ NSCLC who have progressed on or after EGFR TKI therapy (20), and other next-generation irreversible EGFR TKIs in clinical development (Table 1).