On the basis of preclinical observations that afatinib plus cetuximab (an anti-EGFR monoclonal antibody) overcame T790M-mediated resistance (31), this combination was evaluated in a phase Ib trial enrolling 126 heavily pretreated patients with advanced EGFR-mutant NSCLC who had developed resistance to erlotinib/gefitinib. Here, EGFR is linked to non-small cell lung carcinoma.