NOTCH1 and acute lymphoblastic leukemia: For instance, Notch1 mutations occur in over 50% of both pediatric and adult T-cell acute lymphoblastic leukemia (T-ALL) cases (Malyukova et al., 2007; Erbilgin et al., 2010), while Fbxw7 mutations are found in up to 20% of T-ALL cases (Baldus et al., 2009; Mullighan, 2009).