After 2 months of WD, Abca1 (gene for ATP‐binding cassette [ABC] A1), Abcg1 (gene for ABCG1) and Scarb1 (gene for SR‐B1) were reduced; Nr1 h3 (gene for Liver X receptor α) remained unchanged in DKO mice. This evidence concerns the gene ABCA1 and Wilson disease.