The NP cells have a pivotal role in ECM metabolism, providing activated substrates for proteoglycan anabolic and catabolic pathways.32–34 The results of our studies showed that the gene expression of AG, BG and Col2A1 were decreased significantly during the process of IDD, accompanied by a decrease in IAPP expression. The gene discussed is RENBP; the disease is intervertebral disk degenerative disorder.