The present study contributes to reinforce the possible relationship of the canonical Wnt/β-catenin signaling pathway in the process of tumorigenesis in both AME and CCOT, especially because the positive relationship between Wnt1 immunoexpression and cytoplasmic and/or nuclear β-catenin immunoexpression in the epithelium of both AME and CCOT. This evidence concerns the gene WNT1 and apparent mineralocorticoid excess.