In the present series of AME, Wnt5a was identified in about half of the cases, which may be justified by the possibility of this glycoprotein activate or inactivate the canonical Wnt/β catenin signaling pathway and by the fact that AME also present a great variation of radiographic presentation including from minor to major lesions (12,16). The gene discussed is WNT5A; the disease is apparent mineralocorticoid excess.