ESR1 and pulmonary fibrosis: In this section, we apply the Meta-SVM methods to two real examples of idiopathic pulmonary fibrosis expression profiles (IPF; 221 samples in four studies of binary outcome (i.e., case and control)) and breast cancer expression profiles provided by The Cancer Genome Atlas (TCGA) including mRNA, copy number variation (CNV) and epigenetic DNA methylation (http://cancergenome.nih.gov/; 300 samples of estrogen receptor binary outcome (i.e., ER+ and ER-)).