This is exemplified by our observation that CD4+ T cells from patients with cryopyrin-associated periodic syndrome (CAPS) that have constitutively active NLRP3 due to mutations in the NLRP3 gene have increased intrinsic IL-1β production and hyperactive Th1 responses that are unable to switch into normal IL-10 co-production (34). This evidence concerns the gene CD4 and cryopyrin-associated periodic syndrome.