IL6 and Cachexia: These cachectic mediators include TNFα, Myostatin, Activin, other members of the TGF-β superfamily, and the well-known driver of cachexia, Interleukin-6 (IL-6) (Jackman and Kandarian, 2004; Fearon et al., 2012; Tsoli and Robertson, 2013; Narsale and Carson, 2014; Londhe and Guttridge, 2015).