PEG-PLA Nanoparticles with specific siRNA targeting GLUT3 (NPsiGLUT3) significantly reduced the GLUT3 expression in glioma stem cells and bulk glioma cells, and also inhibited the metabolism, proliferation, and downregulated further glioma stem cells percentage (Xu C. F. et al., 2015). This evidence concerns the gene SLC2A3 and central nervous system cancer.