Hence, although it is now known that the glycosylation and trafficking of TREM2 is impaired by NHD-associated mutations such as Y38C and T66M (Kleinberger et al., 2014; Park et al., 2015), it is not yet clear how the biochemical characteristics of TREM2 are affected by the AD-associated R47H variant. This evidence concerns the gene TREM2 and Nasu-Hakola disease.