IL-17A, CXCL1 and CCL20 have however been reported present in other Lyme borreliosis manifestations, such as Lyme arthritis (IL-17), erythema migrans and acrodermatitis chronica atrophicans (CXCL1 and CCL20) [24, 25]. This evidence concerns the gene CXCL1 and Lyme disease.