HE staining revealed the relative uniformity of cancer cell nucleus size in the TP53 wild-type group, and the ratio of the largest and smallest nuleus diameters was 3.4 ± 0.3, which was remarkably smaller than the diameter ratio of 5.4 ± 0.8 for the mutant group (p < 0.05) (Fig. 3a). This evidence concerns the gene TP53 and cancer.