ADAM12 and neoplasm: By comparing the properties of sorted cell populations with high versus medium expression of ADAM12, and by analyzing the effect of ADAM12 knockdown on cell migration, invasion, anoikis resistance, mammosphere formation, known CSC markers, tumor formation after xenotransplantation in mice in vivo, and global gene expression, we have determined that ADAM12 actively supports the CSC phenotype of claudin-low TNBC cells.