For example, ADAM12 was shown to act as a sheddase for heparin-binding EGF-like growth factor (HB-EGF) during cardiac hypertrophy [59] and under hypoxia in head and neck, lung, and pancreatic cancer cells, leading to the formation of invadopodia and increasing cancer cell invasion [60]. The gene discussed is HBEGF; the disease is familial pancreatic carcinoma.