Analysis of TCGA colon adenocarcinoma (COAD) cancer datasets demonstrated a strong correlation between DCLK1 mRNA expression and pro-survival signaling, including CTNNB1, NOTCH1, RELA, PTGS1, and PTGS2, as determined by the Pearson product–moment correlation, as previously described (Fig. 1a). This evidence concerns the gene NOTCH1 and cancer.