HDGFL2 and malaria: Because of the potential for anti-HRP2 Ab to reduce the sensitivity of HRP2-based diagnostic assays, this study sought to establish the prevalence, class, subclass, affinity, and age distribution of Ab to HRP-2 in Cameroonian children and adults, aged 5 to 82  years of age, residing in a malaria-endemic region with high P. falciparum transmission.