In the only cardiovascular outcomes trial of SGLT-2 inhibitors reported to date, the randomized empagliflozin cardiovascular outcome event trial in type 2 diabetes mellitus patients (EMPA-REG OUTCOME) trial of 7020 patients with T2DM and established cardiovascular disease showed that after a median follow up of 3.1 years, empagliflozin was associated with a reduction in the primary composite endpoint of cardiovascular mortality, non-fatal MI, or non-fatal stroke compared with placebo (10.5 vs 12.1%, HR 0.86, 95% CI 0.74–0.99, p = 0.04 for superiority, NNT 62). This evidence concerns the gene SLC5A2 and cardiovascular disorder.