Interference with protection from ischemic preconditioning due to blockade of mitochondrial KATP may contribute to the observed association between sulfonylureas and cardiovascular mortality, although glibenclamide pre-treatment did not abrogate the protective effect of glucagon-like peptide-1 (GLP-1) in human models of non-lethal myocardial ischemia [36]. The gene discussed is GCG; the disease is myocardial ischemia.