BDNF and neuroblastoma: Overexpression of brain derived neurotrophic factor (BDNF) was associated with cisplatin-resistant neuroblastoma (NB) [155], combination chemotherapy with Aurora kinases inhibitor, PHA-680632, suppressed the transcription of BDNF 5′UTR exons 1, 2c, 4 and potentiated the cytotoxic effect of cisplatin in NB cell [156].