MTOR and neoplasm: Furthermore, Sharma et al. reported that combining the Lin28/let-7a/Kras axis inhibitors (NVP-LDE-225 and NVP-BEZ-235) could inhibit tumor growth by inhibiting Bcl-2 family members and activating caspases and by suppressing PI3K-mTOR pathway, suggesting that Lin28/let-7a may be involved in the apoptosis and proliferation of cancer cells simultaneously [47].