Moreover, Wu et al. found that cell fate determination factor Dach1 reduced breast tumor formation in serial transplantations in vivo, further unraveling that in breast cancer cells Dach1 directly bonds to the promoter region of Lin28, Sox2 and Nanog genes and inhibits their expression, finally decreases expansion of CSCs population and blocks breast tumor growth [82]. The gene discussed is LIN28A; the disease is breast carcinoma.