Moreover, Wu et al. found that cell fate determination factor Dach1 reduced breast tumor formation in serial transplantations in vivo, further unraveling that in breast cancer cells Dach1 directly bonds to the promoter region of Lin28, Sox2 and Nanog genes and inhibits their expression, finally decreases expansion of CSCs population and blocks breast tumor growth [82]. This evidence concerns the gene DACH1 and breast cancer.