CUX1 and neoplasm: Further analysis suggested that in most cases the requirement for CUX1 expression in non-irradiated cells is associated with the presence of high ROS levels in tumor cells that carry a RAS mutation (Hs578THRAS, MDA-MB-231HRAS, DLD-1KRAS, HCT116KRAS) or an oncogene that activates the RAS pathway (HT29BRAF and HCC827EGFR) (Figure 1D).