VEGFA and hepatocellular carcinoma: Supplementary Figure 1 shows the three genotypes for VEGF -2578 C>A polymorphism. Compared with the CC genotype, the variant AA and the CA genotypes significantly decreased the risk of developing HCC; the adjusted OR was 0.51 (95% CI = 0.28–0.92) and 0.75 (95% CI = 0.58–0.98), respectively (Table 1).