Regarding microRNA in the signaling pathway downstream of EGFR, we recently suggested that microRNA-31 (miR-31)-5p regulates BRAF activation in colorectal cancer [23, 24] and that high miR-31-5p is associated with survival in patients with colorectal cancer who underwent surgical treatment and chemotherapy with anti-EGFR antibodies [19]. This evidence concerns the gene EGFR and colorectal cancer.