As illustrated in Table 3, E-cadherin low-expression was significantly associated with lymph node (positive vs. negative: OR 1.55, 95% CI 1.15–2.10), tumor size (≥ 2 cm vs. < 2 cm, OR 1.38, 95% CI 1.18–1.60), histological grade (II–III vs. I: OR 1.44, 95% CI 1.06–1.96), TNM stage (T3/T4 vs. T1/T2: OR 2.44, 95% CI 1.75–3.41), and PR status (negative vs. positive: OR 1.44, 95% CI 1.10–1.88). Here, CDH1 is linked to neoplasm.