In order to investigate the function of lncRNA SNHG1 in NSCLC, we reduced expression of SNHG1 by transfecting siRNA specifically targeting SNHG1 (si-SNHG1), qRT-PCR showed that SNHG1 expression was obviously downregulated in si-SNHG1 transfected A549 and SPC-A1 cells compared to cells transfected with si-NC (Figure 2A; P < 0.05). The gene discussed is SNHG1; the disease is non-small cell lung carcinoma.