Single nucleotide polymorphisms (SNP) in UBE2L3 are associated with autoinflammatory conditions, including systemic lupus erythematosus, Crohn’s disease, rheumatoid arthritis, and celiac disease, among others, which implicate UBE2L3 in inflammatory signaling (Amundsen et al., 2014, Fransen et al., 2010, Lewis et al., 2015, Wang et al., 2012, Ye et al., 2016, Zhang et al., 2015, Zhernakova et al., 2011). Here, UBE2L3 is linked to Crohn disease.