In contrast, co-transfection with TSB2, which blocks target site 2, dose-dependently increased expression of RhoA mRNA in HT-29 carcinoma cells transfected with AntagomiR-155-5p (Figure 3C), suggesting that miR-155-5p interacts with this specific target site in RhoA mRNA. The gene discussed is RHOA; the disease is carcinoma.