Numerous regulators exert their functions on NPC progression through regulating SNAIL, such as BMI-1 (ref. 65), EZH2 (ref. 66), LMP1 (ref. 67), EBV-mir-BART7-3p (ref. 68) and ME1 (ref. 69). This evidence concerns the gene ME1 and nasopharyngeal carcinoma.