A similar approach was used by the same authors [27] to test a second seven-gene-panel named ColoSeq on 23 germline DNA samples from Lynch syndrome patients with a known germline mutation, 31 patient samples suspected of Lynch syndrome, 19 samples from subjects with no family cancer history, six samples from the HapMap project and three colorectal cancer cell lines known to carry MMR and/or APC mutations. The gene discussed is APC; the disease is Lynch syndrome.