For instance, a mutation in BRCA1/2 confers a variable lifetime-risk that can be over 80% (ranging from about 40%) for breast cancer [24] and 50%–60% for ovarian cancer (in case of BRCA1 mutation, lower risk for BRCA2 mutation carriers; Table 3 and [25]). The gene discussed is BRCA1; the disease is ovarian carcinoma.