AQP1 and neoplasm: Abnormal tumour microvascular anatomy with reduced density resulting from inhibition of AQP1 expression was also reported by Nicchia and colleagues who tested RNA interference knockdown using AQP1 siRNA on mice subcutaneously implanted with B16F10 mouse melanoma cells, and by Esteva-Font and colleagues who examined the impact of AQP1 deficiency in mouse mammary tumour virus-driven polyoma virus middle T oncogene (MMTV-PyVT) mice which spontaneously developed epithelial cancer [60,61].