The role of hypoxia in induction of AQP1 expression in tumour cells is further supported by Abreu-Rodrigues and colleagues who demonstrated that hypoxia-enhanced transcription of AQP1 through increased activation of the AQP1 promoter and identified putative hypoxia-inducible transcription factor (HIF) binding sites in the promoter region of murine AQP1 gene by bioinformatic analysis [77]. This evidence concerns the gene AQP1 and neoplasm.