Pelagalli and colleagues demonstrated that treatment with bone marrow-derived mesenchymal stem cells (BM-MSCs) conditioned medium increased AQP1 expression with resultant enhanced migration and invasion of U2OS osteosarcoma and SNU-398 hepatocellular carcinoma cells, which were hampered by AQP1 inhibitor, tetraethylammonium chloride [54]. The gene discussed is AQP1; the disease is osteosarcoma.