Chen and colleagues demonstrated infection of 603B cholangiocyte cells with Cryptosporidium parvum, an intracellular parasite, led to recruitment of host-cell AQP1 and SGLT1, a Na+/glucose co-transporter, to the attachment site with resultant localised water influx, and inhibition of AQP1 resulted in reduction in the parasite cellular invasion, which was dependent on host-cell membrane protrusion [45]. The gene discussed is AQP1; the disease is infection.