Isoform-specific quantitative real-time PCR (qRT-PCR) assays performed on total RNA of human monocyte-derived macrophages of CAD patients who are carriers of the “Risk” and “non-Risk” haplotype, demonstrated a significant difference in the OLR1/Loxin mRNA ratio correlating with their haplotype. The gene discussed is OLR1; the disease is coronary artery disorder.