VDR and primary biliary cholangitis: Accordingly, the VDR protein is evenly distributed across normal hepatic parenchyma and bile ductules (Figure 2A,E), whereas in cirrhotic livers of both PBC and PCS patients, the presence of VDR proteins was limited to nodular areas (Figure 2B,F) and irregular ductular structures at the edge of the nodules (Figure 2B,G).