However, in cirrhotic livers of both PBC and PSC patients, SOCS1 proteins were mainly limited to the area of fibrotic tissue surrounding nodules and irregular ductular structures (Figure 4E,F), while numerous FOXP3-positive cells were identified in a thick sleeve of dense fibrous tissue and in abnormal portal tracks (Figure 4H,I). This evidence concerns the gene SOCS1 and pancreatic serous cystadenoma.