PRKAA2 and breast cancer: In humans, grape consumption has been associated with reduced breast cancer risk [21] and it has been demonstrated that MCF-7 breast cancer cells treatment with this compound exerted anti-proliferative effects and induced apoptosis through AMPK activation, that in turn modulated apoptotic pathways such as apoptosis signal-regulating kinase 1/p38 MAP Kinase (MAPK) and cyclooxygenase 2 (COX-2), and inhibited the adenosin/threonine (Akt) pathway [18,22,23].