AMPK also has functions as a regulator of proliferative signals such as mammalian target of rapamycin (mTOR), tuberous sclerosis complex (TSC), ribosomal protein S6 kinase (p70S6) and elongation factor-2, indicating that cancer cell proliferation can be modified via modulating the signaling network through AMPK [11]. This evidence concerns the gene PRKAA1 and cancer.