Likewise, when the flank tumor was allowed to grow for 7 days rather than 4 days prior to AIT treatment, the IL-2, IL-21, IL-2/21, IL-7/15 and IL-7/15/21 groups all had significant slowing of tumor growth or tumor regression when compared to the control or cyclophosphamide-alone groups (Figure 5c; p < 0.03). This evidence concerns the gene IL21 and neoplasm.