In a 4T1 murine mammary cancer model which is weakly immunogenic and aggressively metastatic, we have shown that T cells from tumor antigen-sensitized draining lymph nodes (DLN) can be expanded to significantly greater numbers than the current standard approach using interleukin (IL)-2 alone after exposure to IL-7 and 15, following activation with bryostatin and ionomycin (B/I) [6]. Here, IL7 is linked to neoplasm.