Mice treated with cyclophosphamide alone or cyclophosphamide plus AIT with the standard dose of lymphocytes (50 million cells/mouse intravenously) expanded for 7 days in IL-2, IL-21, IL-2/21, IL-7/15, IL-7/15/21 after 4T1 flank injections (4-day tumor growth) demonstrated significantly better flank tumor shrinkage compared to the control group (Figure 5a; p = 0.02, p < 0.0001, p < 0.0001, p < 0.0001, p < 0.0001, p < 0.0001, respectively). The gene discussed is IL21; the disease is neoplasm.