Consistent with the changes in colon tumor burden, the number of cells expressing Ki-67 was significantly more in colon tumors from Adamts18 KO mice in comparison to WT tumor cells [Ki-67 positive cells (%), WT vs. KO, 50.8 ± 12.9 vs. 72.7 ± 9.2; P = 0.003] (Figure 3C and 3D). This evidence concerns the gene MKI67 and colonic neoplasm.