ADAMTS18 and neoplasm: Immunohistochemistry staining showed that the number of cells with nuclear β-catenin translocation was significantly increased in Adamts18 KO tumor cells compared to WT tumor cells [cells with nuclear β-catenin translocation (%), WT vs. KO, 13.1 ± 2.9 vs. 22.7 ± 4.3; P = 0.0004] (Figure 4A and 4B).