ADAMTS18 and colitis: In DSS-induced colitis model, Adamts18 KO mice showed severe bloody stools and suffered from significant body weight loss from day 6 compared to WT littermates (day 6: WT vs. KO, 94.5 ± 3.8% vs. 90.5 ± 3.2%, P = 0.048; day 7: WT vs. KO, 90.3 ± 3.6% vs. 84.5 ± 2.6%, P = 0.004) (Figure 5A).