In addition, the results of in situ TUNEL assay showed Adamts18 KO tumor cells underwent less apoptosis than WT tumor cells [apoptotic index (%), WT vs. KO, 18.1 ± 4.7 vs. 10.7 ± 3.1; P = 0.0044] (Figure 3E and 3F). This evidence concerns the gene ADAMTS18 and neoplasm.