When we cultured any of four AR+ PCa cell lines (LNCaP, VCaP, LAPC4 and 22Rv1) in N/NC Stem-Transition Medium (STM), they underwent a marked change in morphology, characterized by transition to cells with a rounded body, enlarged nuclei and strikingly distinct nucleoli (Figure 1B) over the period of a week. Here, AR is linked to posterior cortical atrophy.