Our previous data also showed that IL-17B/IL-17RB signaling promoted the expression of stemness-related genes Nanog, Sox2, and Oct4 and enhanced MGC-803 cells efficiently to differentiate into adipocytes [14].In addition, MSCs play an important role in the development of gastric cancers [32].We proposed a hypothesis that IL-17B may also indirectly promote gastric cancer progression by influencing MSCs. The gene discussed is SOX2; the disease is gastric cancer.