Wen-Hwa Lee and co-workers have reported that amplified IL-17B/IL-17RB signaling promoted breast tumorigenes through NF-kB-mediated anti-apoptotic pathway and activated downstream transcription factors NF- kB via ERK1/2 pathway to induce the expression of CCL20, CXCL1, TFF1, and IL-8 in both pancreatic cancer cells and the surrounding stroma [12, 13, 15]. The gene discussed is IL17RB; the disease is familial pancreatic carcinoma.