BRAF and malignant colon neoplasm: For example feedback activation of EGFR has been shown to cause intrinsic resistance to BRAF inhibition in colon cancer (Corcoran et al., 2012; Prahallad et al., 2012), and resistance to BRAF inhibition in melanoma can be caused by reactivation of the MAPK pathway by RTKs, NRAS, or COT (Johannessen et al., 2010; Nazarian et al., 2010).