As suggested earlier, inhibitors of curcumin-mediated induction of Bex genes, wortmannin, SP600125 and pifithrin-α also reduced p53-ser15 phosphorylation significantly indicating the involvement of PI3-kinase like kinases and JNKs in activating p53, which might be associated with curcumin-mediated induction of Bex genes in N2a neuroblastoma cells. Here, TP53 is linked to neuroblastoma.