IKBKB and serum lipopolysaccharide activity: In the current study, we focused on molecular basis of caffeic acid cyclohexylamide (CGA-JK3, Supplementary Fig. 1A) in the treatment of TLRs-associated redundant inflammatory responses in endotoxemia, polymicrobial sepsis or ALF, and proposed IKKβ inhibition as a potential therapeutic target.