The flow cytometric analysis, as shown in Fig. 1, indicated that the miR-34a inhibitors significantly decreased pancreatic cancer cell apoptosis by approximately 20%.However, downregulated expression of Notch1 abrogated the anti-apoptotic effect of the miR-34a inhibitors on pancreatic cancer cells (Fig. 5C). This evidence concerns the gene NOTCH1 and familial pancreatic carcinoma.