Similarly, for the splice site variant in the LPA gene (c.4974-2A>G), which is a protective variant against coronary heart disease (MAFFinns=0.03213; MAFBritons=0.003076; OR=0.84), 36 200 cases and 50 000 controls is required to achieve 80% power at genome-wide significance level in Finns. This evidence concerns the gene LPA and coronary artery disorder.