CCNE1 and cancer: miR‐15b transfection into cancer cells has been shown to lead to decreased expression of Bcl‐2, cyclin E and PIM1 proteins, providing additional mechanistic explanations of how miR‐15b might play an important role in the development drug resistance (Migliore et al., 2008; Weirauch et al., 2013; Xia et al., 2009).