BAG3 and central nervous system cancer: To date, the increasing literature has reported that BAG3 overexpression in glioma cells results in the stimulation of autophagy (Merabova et al. 2015), whereas in osteosarcoma and melanoma cells, it promotes cell survival by sustaining the activation of NF-κB and preventing IKKγ degradation (Ammirante et al. 2010; Rosati et al. 2011).